1. Systemic Toxicity Due to Foodstuffs. - Cardiovascular and Haematological Disease. - Central Nervous System. - Hepatotoxicity. - Renal Toxicity. - References. - 2. Intolerance and Allergy to Foods and Food Additives: Its Relevance to Toxicology. - Allergy Tolerance and Pseudo-allergy (Idiosyncrasy). - Lymphocyte Stimulation and Antibody Formation. - Mucosal (Gastro-intestinal) Immune Systems. - Classification of Allergic Responses. - Anaphylaxis. - Arthus Reaction and Immune Complex Disorders. - Delayed Hypersensitivity (Cell-mediated Immune Response). - Intolerance to Natural Food Chemicals and to Food Additives. - Reduced Immunocompetence (Immunosuppression). - Immunological Tests to Predict Toxicological Allergic Hazards to Man. - References. - 3. Teratogenicity and Reduced Fertility Resulting from Factors Present in Food. - Epidemiological and Expiremntal Aspects. - Food Constituents. - Minerals. - Food Additives. - Alcohol. - Food Contaminants. - Discussion. - References. - 4. Carcinogens in Food. - Carcinogens in Edible Plants. - Fungal Carcinogens. - Carcinogens Introduced During Food Processing and Preservation. - Polycyclic Aromatic Hydrocarbons. - Nitrosamines. - Food Additives. - Pesticides. - Food and Cancer. - Conclusion. - References. - 5. The Mutagenicity of Food. - Principles of Testing Food for Mutagenicity. - Background to Mutagenicity Testing. - Mutagenicity Testing. - Testing Strategy. - Mutagens in Food. - Extrapolation of Results from Laboratory Assays to Man. - Significance of Food-borne Mutagens to Man. - References. - 6. The Gastrointestinal Tract in Food Toxicology. - Role of Gut Microflora in Intestinal Metabolism. - Role of Mammalian Enzymes in Intestinal Metabolism. - Toxicological Aspects of Intestinal Metabolism. - Pathology of the Gastrointestinal Tract in Safety Evaluation. - References. - 7. Food Allergies: Clinical Aspects and Natural Alleigens. - Historical Development. - Clinical Ecology. - Clinical Conditions Related to Clinical Ecology. - Investigation of Food Allergy. - General Discussion. - Summary. - Further Reading. - References. Language: English