This book provides a practical and fairly comprehensive review of Data Science through the lensampampnbspof dimensionality reduction as well as handson techniques to tackle problems with data collected in the real world. Stateoftheart results and solutions from statistics computer science and mathematics are explained from the point of view of a practitioner in any domain science such as biology cyber security chemistry sports science and many others. Quantitative and qualitative assessment methods are described to implement and validate the solutions back in the real world where the problems originated.The ability to generate gather and store volumes of data in the order of tera and exo bytes daily has far outpaced our ability to derive useful information with available computational resources for many domains.This book focuses on data science and problem definition data cleansing feature selection and extraction statistical geometric informationtheoretic biomolecular and machine learning methods for dimensionality reduction of big datasets and problem solving as well as a comparative assessment of solutions in a realworld setting.This book targets professionals working within related fields with an undergraduate degree in any science area particularly quantitative.