Human Chromosomes

1 Origins and Directions of Human Cytogenetics. - 2 The Mitotic Cell Cycle. - 3 DNA Replication and Chromosome Reproduction. - 4 General Features of Mitotic Chromosomes. - 5 The Chemistry and Packaging of Chromosomes. - 6 Chromosome Bands. - 7 Molecular Correlates of Chromosome Bands. - 8 In Situ Hybridization. - 9 Main Features of Meiosis. - 10 Details of Meiosis. - 11 Meiotic Abnormalities: Abnormal Numbers of Chromosomes. - 12 Abnormal Phenotypes Due to Autosomal Aneuploidy or Polyploidy. - 13 Chromosome Structural Aberrations. - 14 The Causes of Structural Aberrations. - 15 Syndromes Due to Autosomal Deletions and Duplications. - 16 Clinical Importance of Translocations Inversions and Insertions. - 17 Sex Determination and the Y Chromosome. - 18 The X Chromosome Dosage Compensation and X Inactivation. - 19 Phenotypic Effects of Sex Chromosome Imbalance. - 20 Fragile Sites Trinucleotide Repeat Expansion and the Fragile X Syndrome. - 21 Euploid Chromosome Aberrations Uniparental Disomy and Genomic Imprinting. - 22 Chromosome Changes in Cell Differentiation. - 23 Somatic Cell Hybridization in Cytogenetic Analysis. - 24 Chromosome Instability Syndromes. - 25 DNA and Gene Amplification. - 26 Genome Destabilization and Multistep Progression to Cancer. - 27 Chromosomes and Cancer: Activation of Oncogenes. - 28 Chromosomes and Cancer: Inactivation of Tumor Suppressor Genes. - 29 Mapping Human Chromosomes. - 30 Genome Plasticity and Chromosome Evolution. - 31 The Future of Human Cytogenetics. Language: English